‘Hidden epidemic’ of neurological deaths in the major Western nations in the 21st Century

Exploring multiple- interactive environmental causes

Authors

  • Colin Pritchard

DOI:

https://doi.org/10.1921/swssr.v25i1.2296

Keywords:

neurological mortality, environmental factors in mental health, diagnosis performance, Gompertzian hypothesi

Abstract

 In the first international comparative study of neurological mortality, which found that between 1989 and 1997, and based on the latest WHO available data, twelve of the twenty-one Western countries had substantial increases in neurological deaths (Pritchard et al., 2004) and by 2021 every-one of the twenty-one Western nations had significant rises in neurological deaths (Pritchard et al., 2013, 2017). In this new study presented here, we use WHO data (WHO, 2020) and the ONS (ONS, 2022) data for England and Wales up to 2020. Previously, increases have been assumed largely due to demography and improved accurate diagnostics (the Gompertzian hypothesis). Our results challenge the idea that the increases are mainly due to demography. We explore the multi-interactive environmental factors that have probably contributed to the rising neurological morbidity, ranging from petrochemicals, organophosphates, endocrine-disruptive chemicals, food additives, plastics, heavy metals in water and human breast milk.

Author Biography

Colin Pritchard

Dr Colin Pritchard, who passed away in January 2023, was Research Professor in Psychiatric Social Work, Faculty of Health and Social Sciences, Bournemouth University. Previously, he was Foundation Professor in Social Work Studies, then Research Professor in Psychiatric Social Work in the School of Medicine, University of Southampton. A recent bibliometric analysis identified him as being in the top 10 most impactful British contributors to social work journal scholarship, and in the top 40 globally.

References

Awata, S., Edahiro, A., Arai, T., Ikeda, M., Ikeuchi, T., Kawakatsu, S., Konagaya, Y., Miyanaga, K., Ota, H., Suzuki, K., Tanimukai, S., Utsumi, K. and Kakuma, T. (2020) Prevalence and subtype distribution of early‐onset dementia in Japan. Psychogeriatrics, 20, 6, 817-823. https://doi.org/10.1111/psyg.12596

Barr, W. and Huxley, P. (1999) The impact of community mental health reform on service users: A cohort study. Health and Social Care in the Community, 7, 2, 129-139.

Batla, A., De Pablo‐Fernandez, E., Erro, R., Reich, M., Calandra‐Buonaura, G., Barbosa, P., Balint, B., Ling, H., Islam, S., Cortelli, P., Volkmann, J., Quinn, N., Holton, J.L., Warner, T.T. and Bhatia, K.P. (2018) Young‐onset multiple system atrophy: Clinical and pathological features. Movement Disorders, 33, 7, 1099-1107. https://doi.org/10.1002/mds.27450

Belpomme, D., Hardell, L., Belyaev, I., Burgio, E. and Carpenter, D.O. (2018) Thermal and non-thermal health effects of low intensity non-ionizing radiation: An international perspective. Environmental Pollution, 242, Pt A, 643-658.

Belyaev, I., Dean, A., Eger, H., Hubmann, G., Jandrisovits, R., Kern, M., Kundi, M., Moshammer, H., Lercher, P., Müller, K., Oberfeld, G., Ohnsorge, P., Pelzmann, P., Scheingraber, C. and Thill, R. (2016) EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses. Reviews on Environmental Health, 31, 3, 63–397. https://doi.org/10.1515/reveh-2016-0011

Carson, R. (1968) The Silent Spring. New York: McMillan.

Chen, G.X., ’t Mannetje, A.M., Douwes, J., van den Berg, L., Pearce, N., Kromhout, H., D’Souza, W., McConnell, M., Glass, B., Brewer, N. and McLean, D.J. (2019) Occupation and motor neuron disease: A New Zealand case–control study. Occupational and Environmental Medicine (London, England), 76, 5, 309-316. https://doi.org/10.1136/oemed-2018-105605

Chiari, A., Vinceti, G., Adani, G., Tondelli, M., Galli, C., Fiondella, L., Costa, M., Molinari, M. A., Filippini, T., Zamboni, G. and Vinceti, M. (2021) Epidemiology of early onset dementia and its clinical presentations in the province of Modena, Italy. Alzheimer’s & Dementia, 17, 1, 81–88. https://doi.org/10.1002/alz.12177

Cuyvers, E., van der Zee, J. and Bettern, K. (2015) Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: A European early-onset dementia consortium study. Neurobiology of Ageing, 15, 36, 15-22.

Darweesh, S.K.L., Ikram, M.K., Faber, M.J., de Vries, N.M., Haaxma, C.A., Hofman, A., Koudstaal, P.J., Bloem, B.R. and Ikram, M.A. (2018) Professional occupation and the risk of Parkinson’s disease. European Journal of Neurology, 25, 12, 1470-1476. https://doi.org/10.1111/ene.13752

de Mettelinge, T., Calders, P. and Cambier, D. (2021) The effects of aerobic exercise in patients with early-onset dementia: A scoping review. Dementia and Geriatric Cognitive Disorders, 50, 1, 9-16. https://doi.org/10.1159/000516231

Easton, D.M. (2005) Gompertzian growth and decay: A powerful descriptive tool for neuroscience. Physiology of Behaviour, 86, 407-414.

Environmental Health Agency. (2021) Federal Court Decision on FCC. www. EHA.com

Farrugia Wismayer, M., Borg, R., Farrugia Wismayer, A., Bonavia, K., Vella, M., Pace, A., Vassallo, N. and Cauchi, R.J. (2021) Occupation and amyotrophic lateral sclerosis risk: A case-control study in the isolated island population of Malta. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22, 7-8, 528-534. https://doi.org/10.1080/21678421.2021.1905847

Fazzo, L., Binazzi, A., Ferrante, D., Minelli, G., Consonni, D., Bauleo, L. and Bruno, C. et al. (2021) Burden of mortality from asbestos-related diseases in Italy. International Journal of Environmental Research and Public Health, 18, 19, 10012.

Fu, P., Guo, X., Cheung, F.M.H. and Yung, K.K.L. (2019) The association between PM2.5 exposure and neurological disorders: A systematic review and meta-analysis. Science and the Total Environment, 655, 1240-1248.

Girardi, P., Merler, E., Ferrante, D., Silvestri, S., Chellini, E., Angelini, A., Luberto, F., Fedeli, U., Oddone, E., Vicentini, M., Barone-Adesi, F., Cena, T., Mirabelli, D., Mangone, L., Roncaglia, F., Sala, O., Menegozzo, S., Pirastu, R., Azzolina, D., Tunesi, S., … Magnani, C. (2020) Factors affecting asbestosis mortality among asbestos-cement workers in Italy. Annals of Work Exposures and Health, 64, 6, 622-635. https://doi.org/10.1093/annweh/wxaa037

Goldacre, M.J., Duncan, M., Griffith, M. and Turner, M.R. (2010) Trends in death certification for multiple sclerosis, motor neuron disease, Parkinson’s disease and epilepsy in English populations 1979-2006. Journal of Neurology, 257, 706-715.

Gore, A.C., Krishnan, K. and Reilly, M.P. (2019) Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior. Hormones and Behavior, 111, 7-22.

Han, L.H., Xue, Y.Y., Zheng, Y.C., Li, X.Y., Lin, R.R. and Wu, Z.Y. (2020) Genetic analysis of Chinese patients with early-onset dementia using next-generation sequencing. Clinical Interventions in Aging, 15, 1831-1839.

Hirano, S., Sakakibara, R., Komatsu, N., Shimizu, K., Ishikawa, M., Hosoi, N., Asahi, T., Shuno, T., Sugihara, H., Kanai, S., Miura, N., Mochida, H., Ozawa, Y., Iyo, M. and Kuwabara, S. (2021) Characteristics of early-onset dementia in Chiba prefecture, Japan: A multicenter survey. Dementia and Geriatric Cognitive Disorders, 50, 3, 283-288. https://doi.org/10.1159/000518294

Huang, L.Y., Hu, H.Y., Wang, Z.T., Ma, Y.H., Dong, Q. and Tan, L. (2020) Association of occupational factors and dementia or cognitive impairment: A systematic review and meta-analysis. Journal of Alzheimer’s Disease, 78, 1, 217-227.

Huxley, P. and Ahmed, N. (2017) Is there a case for using social outcomes in self-harm research? European Psychiatry, 41, S1, S295-S295. https://doi.org/10.1016/j.eurpsy.2017.02.170

Huxley, P. and Evans, S. (2002) Quality of life routine outcomes measurement: Lessons from experience in the USA and the UK. Epidemiology and Social Psychiatry, 11, 3, 192-197.

Huxley, P. and Fitzpatrick, R. (1983) Probable extent of minor mental illness in adult clients of social workers: A pilot study. British Journal Social Work, 14, 174-185.

Huxley, P., Korer, J. and Tolley, S. (1987) The psychiatric caseness of clients referred to an urban social service department. British Journal of Social Work, 17, 507-520

Huxley, P., Reilly, S., Robinshaw, E., Mohamad, H., Harrison, J., Windle, B. and Butler, T. (2003) Interventions and outcomes of health and social care service provision for people with severe mental illness in England. Social Psychiatry and Psychiatric Epidemiology, 38, 1, 44-8.

Huxley, P., Ruud, T., Clausen, H., Ådnanes, M., Poole, R., Siqveland, J., Robinson, C., Nafees, S. and Krayer, A. (2018) Measurement Characteristics of the Manchester Short Assessment of Quality of Life (MANSA): A Systematic Review. CRD 42018114594 ed. NIHR PROSPERO (International Prospective Register of Systematic). https://mc.manuscriptcentral.com/bmjno?DOWNLOAD=TRUE&PARAMS=xik_

WEW1oEXGqSRabc48SYTUkLkD8Gfo4eEe3Pd57yG7uWRizKwdzjDNB2

ddjeaJBhtNZuvDr9HkDZ77dtUR1PrUdVq4WzmFWsfV8aSzWDTvVihRQAGs57T

VAtLTnNi7ypPZcU3YfVDFbhBn5zDfPJiHJrZ27KrGbnpLVyKzTzxEnrn6zRDF1fk5

YSKNcuTGGrkWcfN4

Huxley, P., Krayer, A., Poole, R., Prendergast, L., Aryal, S. and Warner, R. (2021) Schizophrenia outcomes in the 21st century: A systematic review. Brain and Behavior, 11, 6, e02172-n/a. https://doi.org/10.1002/brb3.2172

Huxley, P., Krayer, A., Poole, R., Gromadzka, A., Jie, D. L. and Nafees, S. (2023) The Goldberg–Huxley model of the pathway to psychiatric care: 21st-century systematic review. BJPsych Open, 9, 4, e114–e114. https://doi.org/10.1192/bjo.2023.505

Kalaria, R.N., Maestre, G.E., Arizaga, R., Friedland, R.P., Galasko, D., Hall, K., Luchsinger, J.A., Ogunniyi, A., Perry, E.K., Potocnik, F., Prince, M., Stewart, R., Wimo, A., Zhang, Z.-X. and Antuono, P. (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurology, 7, 9, 812-826. https://doi.org/10.1016/S1474-4422(08)70169-8

Karimi, A., Moghaddam, F.G. and Masoumeh Valipour, M. (2020) Insights in the biology of extremely low-frequency magnetic fields exposure on human health. Molecular Biology Reports, 47, 7, 5621-5633.

Kivimäki, M., Walker, K.A., Pentti, J., Nyberg, S.T., Mars, N., Vahtera, J., Suominen, S.B., Lallukka, T., Rahkonen, O., Pietiläinen, O., Koskinen, A., Väänänen, A., Kalsi, J.K., Goldberg, M., Zins, M., Alfredsson, L., Westerholm, P.J.M., Knutsson, A., Theorell, T., … Lindbohm, J. V. (2021) Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: Three analyses of population cohort studies. BMJ (Online), 374. n1804–n1804. https://doi.org/10.1136/bmj.n1804

Kwak, K., Paek, D. and Zoh, K.E. (2019) Exposure to asbestos and the risk of colorectal cancer mortality: A systematic review and meta-analysis. Occupational and Environmental Medicine, 76, 11, 861-871.

Li, J., Wu, L., Tang, Y., Zhou, A., Wang, F. and Xing, Y. (2018) Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer’s disease. BMC Neurology, 18, 1, 65. https://doi.org/10.1186/s12883-018-1068-6

Loomis, D., Richardson, D.B. and Elliott, L. (2019) Quantitative relationships of exposure to chrysotile asbestos and mesothelioma mortality. American Journal of Industrial Medicine, 62, 6, 471-477.

Luberto, F., Ferrante, D., Silvestri, S., Angelini, A., Cuccaro, F., Nannavecchia, A.M., Oddone, E., Vicentini, M., Barone-Adesi, F., Cena, T., Mirabelli, D., Mangone, L., Roncaglia, F., Sala, O., Menegozzo, S., Pirastu, R., Azzolina, D., Tunesi, S., Chellini, E., … Verdi, S. (2019) Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy. Environmental Health, 18, 1, 71-71. https://doi.org/10.1186/s12940-019-0510-6

Mendez, M.F. (2019) Early-onset Alzheimer disease and its variants. Continuum, 25, 1, 34-51.

Naughton, S.X. and Terry, A.V. (2018) Neurotoxicity in acute and repeated organophosphate exposure. Toxicology, 408, 101-112.

O’Callaghan, J.P. and Miller, D.B. (2019) Neuroinflammation disorders exacerbated by environmental stressors. Metabolism, Clinical and Experimental, 100, 153951–153951. https://doi.org/10.1016/j.metabol.2019.153951

ONS. (2020) Annual Population Survey Estimates of the Country of Birth and Nationality of Residents in England, by Age Group and Sex, 2000 to 2018. www.ons.gov.uk

ONS. (2021) Dementia and Alzheimer’s Disease Deaths Including Comorbidities, England and Wales: 2019 Registrations. Deaths Registered in 2019 in England and Wales due to Dementia and Alzheimer’s Disease, by Sex, Age Group, Ethnicity, Region and Place of Occurrence. Includes Analysis of Comorbidities. www.ons.gov.uk

Panegyres, P.K. and Chen, H.Y. (2014) Early- onset Alzheimer’s disease: A global cross- sectional analysis. European Journal of Neurology, 21, 1149-1154.

Patisaul, H.B. (2021) Endocrine disrupting chemicals (EDCs) and the neuroendocrine system: Beyond oestrogen, androgen, and thyroid. Advances in Pharmacology, 92, 101-150.

Perrone, F., Cacace, R., Van Mossevelde, S., Van den Bossche, T., De Deyn, P.P., Cras, P., Engelborghs, S., van der Zee, J. and Van Broeckhoven, C. (2018) Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis. Neurobiology of Aging, 69, 292.e7-292.e14. https://doi.org/10.1016/j.neurobiolaging.2018.04.015

Pritchard, C. and Rosenorn-Lanng, E. (2015) A controlled study of changing USA neurological deaths of people aged 55-74 and 75+ by gender compared with 20 Western countries 1989-2012: A hypothesis stimulating study. Surgical Neurology International, https://doi.org/10.4103/2152-7806.161420

Pritchard, C., Baldwin, D. and Mayers, A. (2004) Changing patterns of adult [45-74 years] neurological deaths in the major Western world countries 1979-97. Public Health, 116, 1-16.

Pritchard, C., Mayers, A. and Baldwin, D.S. (2013) Changing patterns of neurological mortality in the 10 major developed countries 1979-2010. Public Health, 127, 357-68.

Pritchard, C., Rosenorn-Lanng, E., Silk, A. and Hansen, L. (2017) International and USA population-based study comparing adult [55-74] neurological deaths with control cancer and circulatory disease deaths 1989-2014. Acta Neurologica Scandinavia, 136, 698-707.

Pritchard, C., Silk, A. and Hansen, L. (2019) Are rises in electro-magnetic field in the human environment, interacting with multiple environmental pollutions, the tipping point for increases in neurological deaths in the Western world? Medical Hypothesis, 127, 76-83.

Pritchard, C., Hansen, L., Silk, A. and Rosenorn-Lanng, E. (2021) 21st century early adult (55-74) deaths from brain-disease-Deaths compared to all other cause mortality in the major Western countries – exposing a hidden epidemic. Neurological Research, 43, 900-908.

Rantalainen, V., Lahti, J., Henriksson, M., Kajantie, E., Eriksson, J.G. and Räikkönen, K. (2018) Cognitive ability in young adulthood predicts risk of early-onset dementia in Finnish men. Neurology, 91, 2, e171-e179. https://doi.org/10.1212/WNL. 0000000000005757

Riggs, J.E. and Schochet, S.S. Jr (1992) Rising mortality due to Parkinson’s disease and amyotrophic lateral sclerosis: A manifestation of the competitive nature of human mortality. Journal of Clinical Epidemiology, 45, 1007-1012.

Ross, S.M., McManus, I.C., Harrison, V. and Mason, O. (2017) Neurobehavioral problems following low-level exposure to organophosphate pesticides: A systematic and meta-analytic review. Critical Reviews in Toxicology, 43, 21-44.

Sanchez, A.M., Scharovsky, D. and Romano, L.M. (2015) Incidence of early-onset dementia in Mar del Plata. Neurologia, 30, 77-82.

Santabárbara, J., Gracía-Rebled, A.C., López-Antón, R., Tomás, C., Lobo, E. and Marcos, G. (2019) The effect of occupation type on risk of Alzheimer’s disease in men and women. Maturitas, 126, 61-68.

Sanyal, J., Banerjee, T.K. and Rao, V.R. (2014) Dementia and cognitive impairment in patients with Parkinson’s disease from India: A 7-year prospective study. American Journal of Alzheimers Disease and Other Dementias, 29, 7, 630-636.

Scheffler, C. and Dammhahn, M. (2017) Feminization of the fat distribution pattern of children and adolescents in a recent German population. American Journal of Human Biology, 29, 5. https://doi.org/10.1002/ajhb.23017. May 10. PMID: 28488742.

Scheltens, P., Strooper, D.B., Kiipelto, M., Holstege, H. and Chetelat, G. (2021) Alzheimer’s disease. Lancet Seminar, 397, 1577-1590.

Spina, S., La Joie, R., Petersen, C., Nolan, A. L., Cuevas, D., Cosme, C., Hepker, M., Hwang, J.-H., Miller, Z.A., Huang, E.J., Karydas, A.M., Grant, H., Boxer, A.L., Gorno-Tempini, M.L., Rosen, H.J., Kramer, J.H., Miller, B.L., Seeley, W.W., Rabinovici, G.D. and Grinberg, L.T. (2021) Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease. Brain (London, England: 1878), 144, 7, 2186–2198. https://doi.org/10.1093/brain/awab099

Strand, B.H., Knapskog, A.-B., Persson, K., Holt Edwin, T., Bjertness, E., Engedal, K. and Selbaek, G. (2019) The loss in expectation of life due to early-onset mild cognitive impairment and early-onset dementia in Norway. Dementia and Geriatric Cognitive Disorders, 47, 4-6, 355-365. https://doi.org/10.1159/000501269

Street, M.E., Audouze, K., Legler, J., Sone, H. and Palanza, P. (2021) Endocrine disrupting chemicals: Current understanding, new testing strategies and future research needs. International Journal of Molecular Science, 22, 2, 933. https://doi.org/10.3390/ijms22020933.PMID: 33477789.

Sundström, A., Sörman, D.E., Hansson, P., Ljungberg, J.K. and Adolfsson, R.J. (2020) Mental demands at work and risk of dementia. Alzheimer’s Disease, 74, 3, 735-740.

Terzi, M., Ozberk, B., Deniz, O.G. and Kaplan, S. (2016) The role of electromagnetic fields in neurological disorders. Journal of Chemical Neuroanatomy, 75, Pt B, 77-84. https://doi.org/10.1016/j.jchemneu.2016.04.003. Epub. Apr 12. PMID: 27083321.

Uddin, Md.S., Hasana, S., Ahmad, J., Hossain, Md.F., Rahman, Md.M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A. and Ashraf, G.M. (2021a) Anti-neuroinflammatory potential of polyphenols by inhibiting NF-κB to halt Alzheimer’s disease. Current Pharmaceutical Design, 27, 3, 402-414. https://doi.org/10.2174/1381612826666201118092422

Uddin, Md.S., Kabir, Md.T., Mamun, A.A., Behl, T., Mansouri, R.A., Aloqbi, A.A., Perveen, A., Hafeez, A. and Ashraf, G.M. (2021b) Exploring potential of alkaloidal phytochemicals targeting neuroinflammatory signaling of Alzheimer’s disease. Current Pharmaceutical Design, 27, 3, 357-366. https://doi.org/10.2174/1381612826666200531151004

Velayudhan, L., Baillon, S., Daby, L., Suntharamoorthy, P., Kablan, A., Tromans, S. and Lindesay, J. (2020) Predictors of disease progression in early-onset Alzheimer’s dementia: A retrospective cohort study. Journal of the American Medical Directors Association, 21, 11, 1735-1739. https://doi.org/10.1016/j.jamda.2020.05.016

Wang, V.W., Kandiah, N., Lin, X. and Wee, H.L. (2020) Does health-related quality of life in Asian informal caregivers differ between early-onset dementia and late-onset dementia? Psychogeriatrics, 20, 5, 608-619.

Webber, M. and Huxley, P. (2004) Social exclusion and risk of emergency compulsory admission. A case-control study. Social Psychiatry and Psychiatric Epidemiology, 39, 12, 1000-9.

World Health Organisation. (2020) Annual Mortality. www.who.int/healthinfo/statistics/mortality/whodpmsde Mettelinge, T., Calders, P. and Cambier, D. (2021) The effects of aerobic exercise in patients with early-onset dementia: A scoping review. Dementia and Geriatric Cognitive Disorders, 50, 1, 9-16. https://doi.org/10.1159/000516231

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Published

2024-04-16

How to Cite

Pritchard, C. (2024). ‘Hidden epidemic’ of neurological deaths in the major Western nations in the 21st Century: Exploring multiple- interactive environmental causes. Social Work and Social Sciences Review, 25(1), 47-64. https://doi.org/10.1921/swssr.v25i1.2296